陈庆锋

 

结构生物学

 

陈庆锋，2012年毕业于华中农业大学并获得博士学位，期间先后前往美国唐纳德丹福斯植物科学中心和清华大学开展合作研究，从事植物蛋白的结构和功能研究。2012-2019年在美国西南医学中心/霍华德休斯医学研究所从事博士后研究工作，研究方向为人类重大疾病相关离子通道的结构和功能。相关工作发表在Nature、eLife、PLoS Genetics、JBC 等国际知名学术期刊。2019年10月加入天津大学bat365官网登录入口，任教授。2021年4月全职加入bat365官网登录入口生命科学中心/bat365官网登录入口。

 

 

研究方向

本课题组以X射线晶体学/单颗粒冷冻电镜等结构生物学手段为基础，结合生物化学和细胞生物学等方法，开展与人类疾病密切相关的蛋白质机器的结构和功能研究，特别是定位于细胞器膜上的离子通道/离子转运蛋白等，并基于这些靶标开展相关疾病的药物筛选。

 

欢迎本科生，博士后加入我们的团队，共同探索未知的领域。且欢迎广大科研爱好者来实验室交流，学习，访问，合作。

 

Email：cqf3333@163.com

 

组员

 

 

 

主要论文

1． Chen, Q., Zeng, W., She, J., Bai, X. C., and Jiang, Y. (2019) Structural and functional characterization of an otopetrin family proton channel. Elife 8, e46710.

2． She, J., Zeng, W., Guo, J., Chen, Q., Bai, X. C., and Jiang, Y. (2019) Structural mechanisms of phospholipid activation of the human TPC2 channel. Elife 8, e45222.

3． She, J.*, Guo, J.*, Chen, Q.*, Zeng, W., Jiang, Y., and Bai, X. C. (2018) Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel. Nature 556, 130–134. (*equal contribution)

4． Guo, J.*, She, J.*, Zeng, W., Chen, Q., Bai, X. C., and Jiang, Y. (2017) Structures of the Calcium-activated Non-Selective Cation Channel TRPM4, Nature 552, 205–209. (*equal contribution. Highlighted in "Editors' Choice” in Science Signaling)

5． Chen, Q.*, She, J.*, Zeng, W., Guo, J., Xu, H., Bai, X. C., and Jiang, Y. (2017) Structure of mammalian endolysosomal TRPML1 channel in nanodiscs, Nature 550, 415-418. (*equal contribution. Highlighted in "Editors' Choice” in Science Signaling)

6． Guo, J., Zeng, W., Chen, Q., Lee, C., Chen, L., Yang, Y., Cang, C., Ren, D., Jiang, Y. (2016) Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana. Nature 531, 196-201.

7． Chen, Q.*, Chen, X.*, Wang, Q., Zhang, F., Lou, Z., Zhang, Q., Zhou, D. (2013) Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice. PLoS Genet 9, e1003239. (*equal contribution)

8． Chen, Q., Wang, Q., Xiong, L., and Lou, Z. (2011). A structural view of the conserved domain of rice stress-responsive NAC1. Protein & Cell 2, 55-63.

9． Westfall, C.S., Herrmann, J., Chen, Q., Wang, S., and Jez, J.M. (2010). Modulating plant hormones by enzyme action: the GH3 family of acyl acid amido synthetases. Plant Signal Behav 5, 1607-1612.

10． Chen, Q., Westfall, C.S., Hicks, L.M., Wang, S., and Jez, J.M. (2010). Kinetic basis for the conjugation of auxin by a GH3 family indole-acetic acid-amido synthetase. J Biol Chem 285, 29780-29786.

11． Chen, Q.*, Zhang, B.*, Hicks, L.M., Wang, S., and Jez, J.M. (2009). A liquid chromatography-tandem mass spectrometry-based assay for indole-3-acetic acid-amido synthetase. Anal Biochem 390, 149-154. (*equal contribution)

*共同第一作者

 

实验室管理：

 

联系方式： 

工作单位：bat365官网登录入口/生命科学中心

Center for Life Sciences, School of Life Sciences, Yunnan University, Kunming 650091, China.

单位地址：昆明市呈贡区大学城东外环南路

邮    编：650500

电子邮箱：qingfengchen@ynu.edu.cn